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io ho trovato questo articolo sul Fadogia Agrestis PE

Here are a couple of studies by Dr. Toyin Yakubu- he is a friend of mine from Nigeria who specializes in medicinal plant research at the University of Ilorin. I have talked to him about potentially importing the same extract used in the scientific studies, and we are currently working with the Nigerian government at the moment to try and make this happen.

That being said, I have no idea of what Fadogia Agrestis PE is in terms of plant material (aerial, root, stem, etc.), or if the correct extraction methods dictated in Toyins' studies were even used. Assay/testing methods for Fadogia are underdeveloped at best- I included a study below for your perusal on assay methods used to identify several different glycosides in fadogia. They used NMR, some chemical extraction, and some MS, and in doing so, they isolated some active components. Unfortunately, in some plant species, there can be hundreds, if not thousands of actives, so this may or may not really tell us much, if anything. So, in reality, when you use a product with Fadogia Agrestis PE, it may be hit or miss, depending on the supplier.....

Asian J Androl. 2005 Dec;7(4):399-404. Links
Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats.Yakubu MT, Akanji MA, Oladiji AT.
Medicinal Plants Research Laboratory, Department of Biochemistry, University of Ilorin, PMB 1515, Ilorin, Nigeria.

AIM: To evaluate the phytochemical constituents and the aphrodisiac potential of the aqueous extract of Fadogia agrestis (Rubiaceae) stem in male albino rats. METHODS: The aqueous stem extract of the plant was screened for phytochemical constituents. Male rats were orally dosed with 18 mg/kg, 50 mg/kg and 100 mg/kg body weight, respectively, of the extract at 24 h intervals and their sexual behavior parameters and serum testosterone concentration were evaluated at days 1, 3 and 5. RESULTS: Phytochemical screening revealed the presence of alkaloids and saponins while anthraquinones and flavonoids are weakly present. All the doses resulted in significant increase in mount frequency, intromission frequency and significantly prolonged the ejaculatory latency (P 0.05) and reduced mount and intromission latency (P 0.05). There was also a significant increase in serum testosterone concentrations in all the groups in a manner suggestive of dose-dependence (P 0.05). CONCLUSION: The aqueous extract of Fadogia agrestis stem increased the blood testosterone concentrations and this may be the mechanism responsible for its aphrodisiac effects and various masculine behaviors. It may be used to modify impaired sexual functions in animals, especially those arising from hypotestosteronemia.

J Ethnopharmacol. 2008 Jan 17;115(2):288-92. Epub 2007 Oct 9. Links
Effects of oral administration of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem on some testicular function indices of male rats.Yakubu MT, Akanji MA, Oladiji AT.
Medicinal Plants Research Laboratory, Department of Biochemistry, University of Ilorin, P.M.B. 1515 Ilorin, Nigeria.

AIM OF THE STUDY: The effects of administration of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem on some testicular function indices of male rats (Rattus norvegicus) and their recovery potentials for 10 days were investigated. MATERIALS AND METHODS: Rats were grouped into four: A, B, C and D where A (the control) received orally 1 ml of distilled water (the vehicle), B, C and D (the test groups) received orally on daily basis graded doses of 18, 50 and 100mg/kg body weight of the plant extract, respectively, for 28 days. RESULTS: Compared with the control, extract administration for 28 days at all the doses resulted in significant increase (P<0.05) in percentage testes-body weight ratio, testicular cholesterol, sialic acid, glycogen, acid phosphatase and gamma-glutamyl transferase activities while there was significant decrease (P<0.05) in the activities of testicular alkaline phosphatase, acid phosphatase, glutamate dehydrogenase and concentrations of protein. Recoveries were made by the animals on some of the testicular function indices mainly at 18 mg/kg body weight. CONCLUSIONS: The alterations brought about by the aqueous extract of Fadogia agrestis stem are indications of adverse effects on the male rat testicular function and this may adversely affect the functional capacities of the testes. The recovery made at the dose of 18 mg/kg body weight as used in folklore medicine suggests that it does not exhibit permanent toxicity at this dose.

Phytochemistry. 2008 Feb;69(3):805-11. Epub 2007 Nov 7. Links
Monoterpene glycosides isolated from Fadogia agrestis.Anero R, Díaz-Lanza A, Ollivier E, Baghdikian B, Balansard G, Bernabé M.
Departamento de Farmacognosia, Facultad de Farmacia, Universidad de Alcalá de Henares, Carretera Madrid-Barcelona, Km-33,600, 28871 Alcalá de Henares, Madrid, Spain.

Six monoterpene glycosides were isolated from Fadogia agrestis. Their structures were elucidated using a combination of mass spectroscopy, 1D- and 2D-homo- and hetero-NMR spectroscopy and chemical analysis, and established as being derivatives of 2,6-dimethyl-2(E),6(Z)-octadiene-1,8-diol containing from two to four units of rhamnopyranose and, three of them, one or two additional units of glucopyranose. In three of the compounds an acyl group of 8-hydroxy-2,6-dimethyl-2(E),6(Z)-octadienoyl was found esterifying the O-2 position of one of the units of rhamnopyranose.