Applied Nutriceuticals IGF-2

[farmacologo]

Applied Nutriceuticals IGF-2 240 Capsules

Increase Growth Hormone and Testosterone Release!

IGF-1 is well known for causing rapid muscle and strength gains as well as incredible fat loss and vascularity in all those who have taken it. Now, Applied Nutriceuticals brings you IGF-2 - a next generation supplement designed to increase Growth Hormone and Testosterone output to achieve all the same things as IGF-1 in the form of a groundbreaking supplement.

You’ve got to do a lot of things right to get the massive muscle size, density, strength and hardness you see among the nationally-ranked and pro-level bodybuilders. You’ve got to keep you protein intake high, train aggressively, manage your carb intake, get sufficient rest, etc. But let’s face it…you can do everything right and your gains will be still be limited unless you also do something to increase your testosterone and growth hormone levels. These two hormones are the most anabolic substances know to man – so it’s no wonder that serious bodybuilders administer them directly in various oral and injectable forms. Unfortunately these pharmaceutical-grade preparations are not readily available without a prescription, so for the rest of us, we must find another way.
Only IGF-2 “Immediate Growth Factor” provides the mechanisms to trigger exponential increases in BOTH SERUM TESTOSTERONE AND HUMAN GROWTH HORMONE LEVELS! Better yet, the effects of this ground-breaking formulation can be felt just days after starting. Even hardcore bodybuilders with years of experience with steroids and growth hormone (HGH) rave about this formulation, reporting that it keeps them from “crashing” during off cycles, allowing for continuous, compound muscle growth! Every component of this revolutionary formula either directly or indirectly promotes testosterone and / or HGH production, while also triggering powerful fat-burning mechanisms. The result? Everything you want: Massive increases in muscle size, strength, leanness and density!
The synergistic compounds contained in IGF-2 stimulate a variety of complex reactions and messenger systems in the body, and have been clinically proven to increase testosterone production. IGF-2 contains large amounts of Spirosta-steroidal saponins which are intermediates to numerous hormonal pathways in the body, including testosterone production. When ingested, desoxydiosgenin that is contained in IGF-2 is enzymatically converted to 11-oxa-5 alpha-androstane-3,17-dione, a portion of which is then converted to testosterone through the testes. Increased levels of testosterone signals the muscles to increase protein synthesis and nitrogen retention, leading to greater strength, size and recovery.
IGF-2 drives other dynamic biomechanisms including L-Dopa-induced growth hormone release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can suppress the secretion of gonadotropins, which ultimately hinders testosterone production. The variety of Mucuna Pruriens used in IGF-2 is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule. L-Dopa is a precursor to Dopamine, a powerful biogenic amine, and L-Dopa is the only method of transport of Dopamine through the blood-barrier. L-Dopa-induced GHRH release (growth hormone releasing hormone) signals the pituitary to release HGH. HGH is essentially a polypeptide hormone that stimulates skeletal muscle cells to grow and divide; providing for significant, permanent muscle hypertrophy in adults. HGH also aids in cellular recovery and acts synergistically with testosterone to provide a highly anabolic muscle-building environment.
IGF-2 also stimulates the production of cyclic AMP (cAMP) from ATP. cAMP generation has a variety of effects on tissues, but the most notable is the stimulation of the thyroid to produce thyroxin, which promotes fat metabolization. The increased cAMP levels activate the protein kinase enzyme, which in turn activates hormone-sensitive lipase (HSL) in target tissues. cAMP also signals for the production of luteinizing hormone (LH), which has been shown to elevate testosterone levels in males. Elevated levels of cAMP and LH stimulate a marked increase in the use of fat as body fuel, and are strongly correlated to increased testosterone production.
In a study conducted at the Tomsk State University and Medical Institute in Russia, the form of rhodiola rosea found in IGF-2 demonstrated the ability to stimulate greater ATP enhancement and creatine phosphate storage. Mice were administered rhodiola supplementation and made to swim to exhaustion twice a day for six days. At the end of the testing period, muscle biopsies were performed, and the rhodiola-treated mice were found to have 17% greater ATP levels, 45% greater creatine phosphate stores and 53% greater muscle glycogen levels. Decreased intramuscular concentrations of lactic acid and ammonia were also observed. In human studies, rhodiola has also been shown to have significant stress reduction effects by blocking cortisol release, which helps control muscle breakdown during training and/or stress.
In short; IGF-2 delivers the goods: Explosive growth. Accelerated recovery. Fat metabolization. Anti-catabolism. If you are serious about results, there really is no other choice.
Supplement Facts:
Serving Size: 1 Capsule
Servings Per Container: 240
Amount Per Capsule - 700mg
Chlorophtum Borivilanium (50% extract)
Mucuna Pruriens (standardised to 75% L-Dopa)
Rhodiola Rosea (1% Rosavins)
Dodder Seed Extract (20:1 Cuscutta Chineses)
Bioperine (95 - 98% Peperine) Registered Trademark of Sabinsa Corp. and holds patent # 5,536,506
Inactive Ingredients: Maltodextrin M150, Gelatine, Titanium Dioxide, FD&C Blue #1
FREQUENTLY ASKED QUESTIONS

Q: When is the best time to take IGF-2?

A: Take first dose on an empty stomach first thing in the morning, 45 minutes before a meal. On non-workout days, take second dose in same fashion. On workout days, take second dose 45 minutes before workout, on an empty stomach. Take third dose on an empty stomach 45 minutes before bed time for maximum effectiveness.
Q: How long will it take me to notice the positive anabolic benefits from IGF-2?

A: You will begin to feel the testosterone and growth hormone increases from IGF-2 about 7-10 days after beginning the product, at which point you will notice measurable increases in strength and size. By the end of the third week, you’ll be feeling the full effects of this amazing product with ever-increasing gains in strength, size and density.
Q: What makes IGF-2 different from other anabolics on the market?

A: Not to be cynical, but this one actually works. We are proud that this product delivers exactly what we claim it to. The specifically titrated ratios of the compounds in IGF-2 trigger enormous increases in growth hormone and testosterone production, while serving a critical anti-catabolic function as well. Users of IGF-2 generally report lean body mass gains of 5-7 lbs. over an 8 week cycle, with even greater gains being reported when stacked with NeoVar, our advanced creatine product.
Q: How does IGF-2 boost testosterone levels, and how does testosterone grow more muscle?

A: The safed musli componet of IGF-2 contains large amounts of spirosta-steroidal saponins (desoxydiosgenin, tigogenin and neotigogenin) which are intermediates to various hormonal pathways in the body. When ingested, desoxydiosgenin from the safed musli is enzymatically converted to 11-oxa-5 alpha-androstane-3,17-dione, a portion of which is converted to testosterone through the testes. The testosterone produced binds to the androgen receptor, which signals the muscles via mRNA to increase protein synthesis, increased nitrogen retention and muscle cell hypertrophy; leading to greater strength, mass, and recovery.
Q: How does the L-Dopa in IGF-2 help with testosterone production and growth hormone secretion?

A: The variety of mucuna pruriens used in IGF-2 is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule. Two important mechanisms of action of L-Dopa is increased growth hormone (GH) release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can hinder testosterone production. By inhibiting prolactin, IGF-2 increases endogenous testosterone levels dramatically. L-Dopa is a precursor to Dopamine, a potent GH and testosterone agonist, meaning that dopamine inhibits prolactin release and somatostatin secretion in the hypothalamus, which allows for a greater stimulatory effect of growth hormone-releasing hormone (GHRH) and secretion of testosterone by the testes. GHRH signals the pituitary to release GH, which is produced by the pituitary gland. GH is an important anabolic hormone that stimulates skeletal muscle cells to grow and, in some cases, divide. Acting directly, GH also mobilizes fats from fat depots and decreases the rate of glucose intake and metabolism.
Q: What anabolic and energy-enhancing actions does rhodiola rosea have?

A: Rhodiola rosea has been shown to increase ATP (Adenosine Triphosphate) production in the mitochondria of the cell. ATP is an energy molecule that allows for muscle contraction to occur. In a university study, mice were administered rhodiola and made to swim to exhaustion twice a day for six days. At the end of the testing period, muscle biopsies were performed, with the rhodiola-treated mice having 17% greater ATP levels, 45% greater creatine phosphate stores, and 53% greater muscle glycogen levels, along with lowered intramuscular concentrations of lactic acid and ammonia. What this means to you is stronger muscle contraction, allowing for improved energy and stamina.
In human studies, the rosavin and salidroside found in rhodiola rosea have also been shown to have significant effects on stress reduction. This is accomplished by reducing cortisol release, while optimizing levels of key brain chemicals involved in mood, such as serotonin and dopamine, which function together to maintain a healthy response to stress. Blocking cortisol is important, as cortisol tends to break down muscle tissue, increase body fat stores, slows the metabolism and lowers immune function. Rhodiola has been shown to have adaptogenic qualities, meaning that it allows humans to work harder during stress, while at the same time maintaining higher energy reserves.
Q: Should I cycle IGF-2?

A: Yes- we recommend that IGF-2 be taken in 8-10 week cycles to maximize effectiveness. The user should allow thirty days to pass before commencing a new cycle. Many use a two months on, one-month off philosophy with outstanding results.
Q: Who can benefit from IGF-2?

A: Any serious athlete or bodybuilder looking to gain size and/or strength and speed recovery time. Endurance athletes can also benefit from IGF-2 as well; testing with IGF-2 was performed on Olympic-level track athletes who experienced measurable incremental improvements in speed plus reductions in muscle fatigue. Extensive testing has been also been conducted with nationally-ranked and IFBB pro bodybuilders and competitive power lifters, and the results in terms positive effects/benefits have been phenomenal. Additionally, all ingredients comply with IOC, NCAA, NFL, NBA, and MLB banned substances lists.

TECHNICAL WRITE UP

Applied Nutriceuticals Research is proud to introduce the newest and most effective anabolic product on the market, IGF-2. IGF-2 is a powerful blend of the strongest legally available herbal compounds, perfectly standardized to provide the highest quality and effectiveness. IGF-2 incorporates Safed Musli, Mucuna Pruriens, Dodder Seed, and Rhodiola Rosea combined into a specific, synergistic formula that produces amazing results faster than would ever be expected from an over-the-counter preparation.

Safed Musli is an Ayurvedic herb used for centuries to improve physical strength and male fertility. We now know that this due to the high concentrations of spirosta-steroidal saponins found in this compound, which have been shown to significantly increase testosterone levels (1,2,3,6). Mucuna Pruriens, another Ayurvedic herb, contains high concentrations of L-Dopa, a compound responsible for increasing endogenous GH and testosterone secretion (15). Dodder Seed (Cuscuta Chineses) is an herb used by the Chinese for centuries to treat male impotence and infertility, which has been shown to increase cAMP production (cyclic AMP – a precursor to ATP, the primary cellular energy molecule), as well as testosterone levels (26). Rhodiola Rosea is an adaptogenic herb that has been shown in animal studies to boost ATP, glycogen, and Creatine Phosphate levels, and has been shown in humans to decrease physiological stress while increasing memory, alertness, and energy (23,24,25).
Product Overview: IGF-2 and Hormonal Systems
The compounds contained in IGF-2 stimulate a variety of complex reactions and messenger systems in the body, most notably through direct gene activation and the second messenger system. Safed Musli, Mucuna Pruriens, and Dodder Seed all have been shown to increase testosterone production in the body via a number of different mechanisms (1,2,26,27).
Testosterone Production
Safed Musli, in particular, contains large amounts of Spirosta-steroidal saponins: desoxydiosgenin, tigogenin, neotigogenin, which are intermediates to various hormonal pathways in the body (1,2). When ingested, desoxydiosgenin from Safed Musli is enzymatically converted to 11-oxa-5 alpha-androstane-3,17-dione, some of which is converted to testosterone through the testes. The increased testosterone produced by this process binds to the androgen receptor (AR), signaling the muscles via mRNA to increase protein synthesis and nitrogen retention, leading to greater strength, mass, and recovery (1,2,27).
Testosterone, which is lipid soluble, diffuses through the cell wall, binding to the intracellular androgen receptor (AR). The binding causes an activation of the hormone receptor, and the activated receptor complex continues on to the nucleus of the cell, where the hormone binds to a DNA receptor protein. This signals the transcription of DNA to produce mRNA(3). The mRNA is then transplanted to the ribosomes of the cell, signaling the body to increase protein synthesis in a variety of target tissues (skeletal muscle) (3).
L-Dopa and its effects on Testosterone and Human Growth Hormone
Another important chemical mechanism of IGF-2™is L-Dopa-induced growth hormone (GH) release, and increased testosterone secretion through prolactin inhibition. Prolactin is a hormone that regulates testosterone production, and too much of it can suppress the secretion of gonadotropins, which hinders testosterone production. By inhibiting prolactin, IGF-2 increases endogenous testosterone levels dramatically. The variety of Mucuna Pruriens used in IGF-2 is standardized to 25% L-Dopa, delivering large amounts of this active ingredient per capsule (27). L-Dopa is a precursor to Dopamine, a powerful biogenic amine, and L-Dopa is the only method of transport of Dopamine through the blood-barrier(3,15,16). Dopamine is a potent GH and testosterone agonist, meaning that dopamine inhibits prolactin release and hypothalamic somatostatin secretion, which allows for a greater stimulatory effect of growth hormone-releasing hormone (GHRH) and secretion of testosterone by the testes. GHRH signals the pituitary to release GH, a polypeptide hormone produced by the somatotropic cells of the anterior pituitary (3,11,12,14,15,16). GH stimulates skeletal muscle cells to grow and, in some cases, divide. Acting directly, GH mobilizes fats from fat depots and decreases the rate of glucose intake and metabolism. In mammals, GH exerts most of its anabolic effects through being mediated by IGF; IGF is also known as somatomedin, which stimulates the uptake of amino acids from the blood and into skeletal muscle, providing for a variety of anabolic effects in the human body. This is important, as IGF-2 provides the biochemical stimulus for the aforementioned muscle-building processes.
Dodder Seed, Rhodiola Rosea
Dodder Seed is another important component of IGF-2 as it also activates the second messenger system, and subsequently causes adenylate cyclase to generate cAMP from ATP (3,26). cAMP generation has a variety of effects on tissue and glandular activity, but the most notable is the stimulation of the thyroid to produce thyroxin (promoting elevated fat burning). Increased cAMP levels to also activate the protein kinase enzyme, which in turn activates hormone-sensitive lipase (HSL) in targeted tissues(10,11,13) and signals for the production of luteinizing hormone, which elevates testosterone levels in males. Elevations in these two hormones can cause a marked increase in fat as body fuel, as well as a strong correlation to decreased body fat and increased muscle mass, density and strength.
Rhodiola Rosea also displays some individualistic qualities of greater ATP enhancement and creatine phosphate storage in animal studies. At the Tomsk State University and Medical Institute in Russia, mice were administered Rhodiola supplementation and made to swim to exhaustion twice a day for six days. At the end of the testing period, muscle biopsies were performed, with the Rhodiola-treated mice having 17% greater ATP levels 45% greater creatine phosphate stores, and 53% greater muscle glycogen levels, while having lower intramuscular concentrations of lactic acid and ammonia (23,24,25). The rosavin and salidroside content of Rhodiola Rosea has also been shown to have significant effects on stress reduction in human studies by reducing cortisol release, while optimizing levels of key brain chemicals such as serotonin and dopamine that function together to maintain a healthy response to stress (20-25). Blocking cortisol is a very important effect, as cortisol breaks down muscle tissue and increases body fat, slowing the metabolism and lowering immune function. Rhodiola has been shown to also have adaptogenic qualities, allowing the human body to work harder during stress, while at the same time maintaining higher energy reserves (20-25). This is important to hard-training athletes because intense stress and strain can cause significant increases in stress hormone levels like cortisol (20-25), thus diminishing results.
Synergy
The ingredients in IGF-2, precisely blended to optimal ratios together produce a powerful synergistic combination. Synergism of hormones occurs in situations where more than one hormone produces the same effects at the target cell, and their combined effects are amplified. Safed Musli contains large amounts of the spirosta-steroidal saponins and Mucuna Pruriens, as mentioned before, converts to L-Dopa. L-Dopa converts to dopamine, which increases testosterone (via prolactin inhibition) and growth hormone through an increase in GHRH release (1,10,11,12,16,17,18,27). GH converts to IGF-1, and exerts anabolic effects in skeletal muscle. Also, and even more importantly, hormonal compounds (like desoxydiosgenin) can increase IGF-1 in muscle tissue as well, and maybe even aid in the ability of the skeletal muscles to use GH and IGF. Increased testosterone also tells the body to continue producing GH endogenously, stopping the negative feedback loop (10-12). In conclusion, IGF-2 employs powerful inter-compound synergism, leading to more rapid muscular growth, along with increased recovery and noticeable strength increases.

[farmacologo]

Discutiamo di questo prodotto...la Applied Nutriceuticals è una casa che conosco perchè fa la Neovar una delle migliolri creative in commercio, per il resto non so molto di questo prodotto ma dalle caratteristiche sembra interessante...

[farmacologo]

Ovviamente, contenedo la Mucuna Pruriens, è vietato in italia.

[greatescape]

l'evoluzione di questo prodotto è stato hgh up
di solito chi prende questi prodotti vede quasi sempre un miglioramento nella qualità del sonno e del riposo, miglior recupero quindi, a volte anche un certo dimagrimento e un miglior bilanciamento della massa magra sulla grassa
per certi versi non mi hanno mai dato fiducia trovandoli anche sempre un po' troppo costosi

mi piacerebbe sapere cosa ne pensa thehuge di questo ingrediente Cholorophytum Borivilanium dato che secondo l'applied questo ingrediente secondo certi studi avevi dei risultati simili a quelli del testosterone secondo gli studi riportati

questo ingrediente è stato usato per l'alpha-x prodotto per il mercato europeo quindi con pochi feedback online

[farmacologo]

Originariamente inviato da greatescape

l'evoluzione di questo prodotto è stato hgh up
di solito chi prende questi prodotti vede quasi sempre un miglioramento nella qualità del sonno e del riposo, miglior recupero quindi, a volte anche un certo dimagrimento e un miglior bilanciamento della massa magra sulla grassa
per certi versi non mi hanno mai dato fiducia trovandoli anche sempre un po' troppo costosi

mi piacerebbe sapere cosa ne pensa thehuge di questo ingrediente Cholorophytum Borivilanium dato che secondo l'applied questo ingrediente secondo certi studi avevi dei risultati simili a quelli del testosterone secondo gli studi riportati

questo ingrediente è stato usato per l'alpha-x prodotto per il mercato europeo quindi con pochi feedback online

Interessante, nell' HGH Uo guardando agli ingredienti :

Somatotrophic-Myonucleic Growth Factor™3500mgmg
Chlorophytum Borivilanium (75% Extract)*, L-Carnitine L-Tartrate*, Green Tea (98% Polyphenol 50% EGCG)*, Mucuna Pruriens (Standardized To 75% L-Dopa)*, Magnesium (As Magnesium Carbonate), B-Complex, Bioperine (95-98% Piperine)**, Huperzine-A (Huperzia Serrata 5% Extract)*, Selenium
Sono passato da un estratto di mucuna del 25% ad uno del 75%...interessante il fatto che abbia un effetto positivo sul sonno...quando ad esempio il forskolin è noto creare problemi di insonnia...

[THEHUGE]

Originariamente inviato da greatescape

l'evoluzione di questo prodotto è stato hgh up
di solito chi prende questi prodotti vede quasi sempre un miglioramento nella qualità del sonno e del riposo, miglior recupero quindi, a volte anche un certo dimagrimento e un miglior bilanciamento della massa magra sulla grassa
per certi versi non mi hanno mai dato fiducia trovandoli anche sempre un po' troppo costosi

mi piacerebbe sapere cosa ne pensa thehuge di questo ingrediente Cholorophytum Borivilanium dato che secondo l'applied questo ingrediente secondo certi studi avevi dei risultati simili a quelli del testosterone secondo gli studi riportati

questo ingrediente è stato usato per l'alpha-x prodotto per il mercato europeo quindi con pochi feedback online

Il safed musli sembra promettente su modelli animali ma ad essere franco prima di avventurarmi in un eventuale giudizio vorrei testarne personalmente gli effetti. E' tra i pochi estratti con i quali non ho ancora giocato un po'...

[jim_a]

esami di sangue di un amico she ha usato hgh up

testo totale 3,41 ng/ml 2,6 - 9,0
testo libera 62,2 pg/ml 5,5 - 50,00
estradiolo Ε2 24,3 pg/ml 5 - 70
estrone Ε1 1421 pgr/ml 20-150

non ho la baseline me le ha mandate cosi

non ho la minima idea perche l'estrone e cosi alto

la testo libera e aumentata

[farmacologo]

Originariamente inviato da jim_a

esami di sangue di un amico she ha usato hgh up

testo totale 3,41 ng/ml 2,6 - 9,0
testo libera 62,2 pg/ml 5,5 - 50,00
estradiolo Ε2 24,3 pg/ml 5 - 70
estrone Ε1 1421 pgr/ml 20-150

non ho la baseline me le ha mandate cosi

non ho la minima idea perche l'estrone e cosi alto

la testo libera e aumentata

Il testo totale è basso...normalmente dovrebbe aggirarsi intorno a valori come 6 o 7 in un soggetto sano...forse una conseguenza dell' elevato testo libero ?

[jim_a]

ma non dovrebe essere alto l'estradiolo???

[farmacologo]

Originariamente inviato da jim_a

ma non dovrebe essere alto l'estradiolo???

Con un testo così basso è normale che sia a quei valori...

[jim_a]

ma dall aumento dell testo libero non dovrebe aumetare l'estradiolo?

l'aromatazi agisce sull testosterone e lo converte in estradiolo

mentre l'androstendione viene convertito in estrone e l'estrone in estradiolo

no so se ho detto una c@@@@???!!!!???

[menphisdaemon]

Farmacologo la casa produttrice è trustable che tu sappia? Io francamente non la conosco purtroppo.

Cmq dichiarare un aumento tra le 5 e le 7 lbs in 8 settimane francamente mi sa di eccessivo...manco fosse un ciclo di AAS. Cmq molto molto interessante...aspetto feedback e pareri del nostro THEHUGE.

[farmacologo]

Originariamente inviato da menphisdaemon

Farmacologo la casa produttrice è trustable che tu sappia? Io francamente non la conosco purtroppo.

Cmq dichiarare un aumento tra le 5 e le 7 lbs in 8 settimane francamente mi sa di eccessivo...manco fosse un ciclo di AAS. Cmq molto molto interessante...aspetto feedback e pareri del nostro THEHUGE.

La casa produttrice è assolutamente trustabile, produce la Neovar che è la migliore creatina in commercio.

[farmacologo]

Originariamente inviato da jim_a

ma dall aumento dell testo libero non dovrebe aumetare l'estradiolo?

l'aromatazi agisce sull testosterone e lo converte in estradiolo

mentre l'androstendione viene convertito in estrone e l'estrone in estradiolo

no so se ho detto una c@@@@???!!!!???

A meno che non abbia usato un AI...

[farmacologo]

Originariamente inviato da jim_a

ma dall aumento dell testo libero non dovrebe aumetare l'estradiolo?

l'aromatazi agisce sull testosterone e lo converte in estradiolo

mentre l'androstendione viene convertito in estrone e l'estrone in estradiolo

no so se ho detto una c@@@@???!!!!???

Si comunque considerando che un nanogrammo sono 0,000000001 grammi e che un picogrammo sono 0,000000000001 g la quantita di testosterone libero non è sufficiente per influenzare l' attività aromatasica...