Stimolatori di ossido d'azoto e caffeina

duchaine · **Stimolatori di ossido d'azoto e caffeina -** 03-12-2007, 05:53 PM

Ho letto delle cose poco convincenti sul rapporto tra caffeina e stimolatori del nitrato di azoto su di un forum americano e sono intenrvenuto. In particolare, ci si chiedeva se la caffeina potesse essere presa o meno durante l'integrazione di arginina.
A questa domanda, facevano seguito due risposte opposte e male argomentate:
1)alcuni sostenevano che la caffeina andrebbe avitata quando si prende uno stimolatore di No, perchè la caffeina è vasocostrittore; 2) altri ritenevano che i due supplementi andrebbero combinati... perchè la BSN li mixa nel no-xplode!

Questa, invece, la mia risposta:

The relation btw caffeine and no stimulators is totally overlooked, and a study about this point would be really appreciated (If I'll have time, I'll write something about it).

Some people suggest to avoid caffeine because it is a vasoconstrictor; but IMHO, I think they are wrong.

Caffeine works (ie: exherts its metabolic action) mainly trought 2 mechanisms: a) it stimulates nor-adrenaline production; b) it elevates cAMP (caffeine acts as phosphodiesterase inhibitors and this prolongs the action of cAMP).

a)When people say that nor-adrenaline is "vasoconstrictor", they don't consider that this is only partially true.
When nor-adr. binds to a1 adrenoreceptors, it causes vasoconstriction; when it binds to b2 adrenoreceptors, it cause vasodilatation.
When we rise noradrenaline, it causes both vasoconstriction and vasodilatation. I mean, "catecolamines cause direct stimulation of a- and b- adrenergic receptors. Its effects on the peripheral vasculature are mixed. It has mainly a1 stimulating properties in some vascular beds (skin, mucosa and kidney) and b2 stimulating properties in others (skeletal muscle)".
So caffeine, trought noradrenaline stimulation, causes vasodilatation in skeletal muscle, as well as NO does (i.e.: as well as No stimulators do!).

b) cAMP activation in the smooth muscles of vascular walls leads to relaxation and expansion of the blood vessels, allowing for more blood to travel into tissues, including skeletal muscle.
This mean that caffeine can increase blood flow.

In summary, caffeine can work sinergically with vasoflow, nitrix etc., leading to greater pump.

At this point, the reader could ask "why the fu..ing hell, San people suggest to avoid caffeine while on vasoflow?!".
I don't know. Several year I could ask to Nandi, but he passed away.
At the moment, I can figure that the "rationale" behind their claim is to avoid cardic problems.

Duch (che fino a 10 anni fa era bilingue...oggi fa fatica a scrivere due paroline pecorecce!)

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duchaine Rookie Messaggi: 24 Data registrazione: Nov 2007 Località: napoli Età: 47	Stimolatori di ossido d'azoto e caffeina - 03-12-2007, 05:53 PM Stimolatori di ossido d'azoto e caffeina Ho letto delle cose poco convincenti sul rapporto tra caffeina e stimolatori del nitrato di azoto su di un forum americano e sono intenrvenuto. In particolare, ci si chiedeva se la caffeina potesse essere presa o meno durante l'integrazione di arginina. A questa domanda, facevano seguito due risposte opposte e male argomentate: 1)alcuni sostenevano che la caffeina andrebbe avitata quando si prende uno stimolatore di No, perchè la caffeina è vasocostrittore; 2) altri ritenevano che i due supplementi andrebbero combinati... perchè la BSN li mixa nel no-xplode! Questa, invece, la mia risposta: The relation btw caffeine and no stimulators is totally overlooked, and a study about this point would be really appreciated (If I'll have time, I'll write something about it). Some people suggest to avoid caffeine because it is a vasoconstrictor; but IMHO, I think they are wrong. Caffeine works (ie: exherts its metabolic action) mainly trought 2 mechanisms: a) it stimulates nor-adrenaline production; b) it elevates cAMP (caffeine acts as phosphodiesterase inhibitors and this prolongs the action of cAMP). a)When people say that nor-adrenaline is "vasoconstrictor", they don't consider that this is only partially true. When nor-adr. binds to a1 adrenoreceptors, it causes vasoconstriction; when it binds to b2 adrenoreceptors, it cause vasodilatation. When we rise noradrenaline, it causes both vasoconstriction and vasodilatation. I mean, "catecolamines cause direct stimulation of a- and b- adrenergic receptors. Its effects on the peripheral vasculature are mixed. It has mainly a1 stimulating properties in some vascular beds (skin, mucosa and kidney) and b2 stimulating properties in others (skeletal muscle)". So caffeine, trought noradrenaline stimulation, causes vasodilatation in skeletal muscle, as well as NO does (i.e.: as well as No stimulators do!). b) cAMP activation in the smooth muscles of vascular walls leads to relaxation and expansion of the blood vessels, allowing for more blood to travel into tissues, including skeletal muscle. This mean that caffeine can increase blood flow. In summary, caffeine can work sinergically with vasoflow, nitrix etc., leading to greater pump. At this point, the reader could ask "why the fu..ing hell, San people suggest to avoid caffeine while on vasoflow?!". I don't know. Several year I could ask to Nandi, but he passed away. At the moment, I can figure that the "rationale" behind their claim is to avoid cardic problems. Duch (che fino a 10 anni fa era bilingue...oggi fa fatica a scrivere due paroline pecorecce!)