|
Integrazione L'azione fisiologica, i protocolli d'assunzione, le materie prime ed i prodotti in commercio. Discutiamone senza censure e veti commerciali
Ciao amico visitatore, cosa aspetti? Apri una discussione subito nella sezione Integrazione |
|
LinkBack | Strumenti Discussione | Modalità Visualizzazione |
(#1)
|
|
Guybrush
Messaggi: 3,950
Data registrazione: Feb 2005
Età: 39
|
effetto positivodel nac -
19-11-2008, 12:36 AM
effetto positivodel nacTo study the effects of N-acetylcysteine (NAC, C(5)H(9)-NO(3)S) on high-sucrose diet-induced obesity and its effects on energy metabolism and cardiac oxidative stress, male Wistar 24 rats were divided into four groups (n=6): © given standard chow and water; (N) receiving standard chow and 2g/l N-acetylcysteine in its drinking water; (HS) given standard chow and 30% sucrose in its drinking water, and (HS-N) receiving standard chow, 30% sucrose and N-acetylcysteine in its drinking water. After 30 days of the treatment, obesity was evidenced in HS rats from enhanced body weight, respiratory quotient, hypertriglyceridemia, as well-depressed resting metabolic rate, and oxygen consumption per surface area. HS rats had triacylglycerol accumulation, oxidative stress and metabolic shifting in cardiac tissue. NAC enhanced fat oxidation and energy expenditure, normalizing these adverse effects, comparing HS-N and HS rats. The beta-hydroxyacyl coenzyme-A dehydrogenase activity was higher in HS-N animals, indicating higher heart fatty acid degradation than in HS. NAC normalized myocardial glycogen and lactate dehydrogenase activity, comparing HS-N and HS rats, but had no effects on calorimetric and biochemical parameters in standard-fed rats, comparing N and C groups. In conclusion, N-acetylcysteine offers promising therapeutic value in prevention of high-sucrose induced-obesity and its effect on cardiac tissue. N-acetylcysteine reduced the oxidative stress and prevented the metabolic shifting in cardiac tissue, enhancing fatty acid oxidation and reducing anaerobic metabolism in high-sucrose-fed conditions. The application of this agent in food system via exogenous addition may be feasible and beneficial for antioxidant protection and energy metabolism in cardiac tissue. |
|
|
(#2)
|
|
Guybrush
Messaggi: 3,950
Data registrazione: Feb 2005
Età: 39
|
19-11-2008, 01:05 AM
Department of Neurology, Keimyung University School of Medicine and Institute for Medical Science, 194 Dongsan-Dong, Jung-Gu, Daegu 700-712, Korea. N-acetylcysteine (NAC), an antioxidant and a precursor of glutathione, is currently in clinical use for various pathological conditions. No data is available as to the relationship between NAC and muscular cell proliferation or muscular degenerative disease. In this study, we assessed the effect of NAC on growth of L6 myoblasts, a rat skeletal muscle cell line, under normal or bupivacaine-treated condition. Of interest, under normal growth conditions, NAC treatment concentration-dependently increased viability, cell number, and DNA incorporation of L6 cells. Remarkably, NAC treatment for 12 to 24 h led to increased phosphorylation of ERKs, a family of mitogen-activated protein kinase known to involve in cell proliferation, in L6 cells, and specific inhibition of ERKs by PD98059, a selective inhibitor of ERKs, greatly abolished the ability of NAC to increase the number of L6 cells. More importantly, pretreatment with NAC effectively blocked decrease in the number and ERKs phosphorylation in L6 cells induced by the exposure of bupivacaine, a local anesthetic with myotoxicity. These results collectively suggest that NAC has muscular cell proliferative and protective effects and the effects by NAC appear to be, in part, mediated via increase in ERKs activation. |
|
|
(#3)
|
|
All the Truth Member
Messaggi: 20,462
Data registrazione: Jun 2007
|
19-11-2008, 02:41 AM
facci il succo del discrso ora non c'e' scritto le quntita dello studio pero ??? |
|
|
(#4)
|
|
RealUncensoredMofo
Messaggi: 420
Data registrazione: Feb 2008
Età: 40
|
19-11-2008, 02:43 AM
nooo,il copia e incolla no volevo leggere qualcosa di tuo homer. |
|
|
Strumenti Discussione | |
Modalità Visualizzazione | |
|
|