Testosterone-Propionate

**Antò** · 09:05 PM

(testosterone propionate)

As we all know, Testosterone was the first steroid to be synthesized. Now, it remains the gold standard of all steroids. First, we´ll discuss Testosterone in general, and in depth, then we´ll examine exactly how (and what) the propionate ester is (together, testosterone propionate is often referred to as just "prop" or "test prop").
Testosterone´s anabolic/androgenic ratio is 1:1 meaning it is exactly as anabolic as it is androgenic. Actually, testosterone is the steroid which all anabolic/androgenic ratio´s are based on. If a steroid is 2:1, then it is, compared with testosterone´s ratio, doubly as anabolic as it is androgenic. Hence, we see from testosterone´s ratio, it is both quite anabolic as well as androgenic.
So how exactly does Testosterone build muscle? Well, Testosterone promotes nitrogen retention in the muscle (6), and the more nitrogen the muscles holds the more protein the muscle stores, and the bigger the muscle gets. Testosterone can also increase the levels of another anabolic hormone, IGF-1, in muscle tissue (7). IGF-1 is, alone, highly anabolic and can promote muscle growth. It is responsible for much of the anabolic activity of Growth Hormone (GH). IGF-1 is also one of the few hormones positively correlated with both muscle cell hyperplasia and hyperphasia (this means it both creates more muscle fibers as well as bigger fibers). All of this leads me to speculate that for pure mass, IGF-1, GH, and Testosterone would be a very effective combination. Testosterone also has the amazing ability to increase the activity of satellite cells(8). These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor (A.R.) to promote all of the A.R dependant mechanisms for muscle gain and fat loss (9), but clearly, as we´ve seen, this isn´t the only mechanism by which it promotes growth.
Testosterone has a profound ability to protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones (11), and increase red blood cell production (12), and as you may know, a higher RBC count may improve endurance via better oxygenated blood. The former trait increases nitrogen retention and muscle building while the latter can improve recovery from strenuous physical activity, as well as increase endurance and tolerance to strenuous exercise.
Testosterone occurs naturally in both the male and female body, as insofar as drug testing for it, typical tests don´t work (i.e. testing for metabolites). Testosterone can be tested for on a testosterone/epitestosterone ratio, a failing result usually being anything over 6 to 1, but there are other more effective tests currently in use as well as being developed by the usual party-poopers in the IOC and FDA. Noteworthy is that if you are using low doses of this drug and stop taking it 36-48 hours before a Test/EpiTest analysis, you can still pass!
Testosterone, once in the body, can be converted to both estrogen (via a process known as aromatization) as well as DHT. Estrogen is the main culprit for many side effects such as gyno, water retention, etc...while DHT is often blamed for hair loss and prostate enlargement. Naturally there are ways to combat this, such as using an anti-estrogenic compound along with testosterone, or even an estrogen blocker. DHT can be combated (on the scalp, to prevent hair loss) with compounds such as Ketoconazole shampoo (sold under the trade name Nizoral) as well as Finasteride (sold as Proscar in the 5mg version and as Propecia as 1mg tablets). Interestingly, this shampoo can also be used topically to combat acne on the face (or even the back if you´re really flexible). Both of these methods for preventing hair loss and acne are reasonably effective. However, if you are not prone to hair loss, they may be wholly unnecessary. Male Pattern Baldness (MPB) is carried by the X chromosome, so if your mother´s family boasts men with full heads of hair, then you are probably safe (unless those full heads of hair are all mullets). Naturally, as with most other steroids, your lipid profile is going to suffer a bit while on testosterone as is your blood pressure. This, of course is nothing that can´t be controlled by watching your diet and doing your cardio, at least for the duration of the typical cycle (which for arguments sake, I´ll assume is +/- 12 weeks). Lets be totally honest, here, even a modest amount of exercise will improve your blood pressure and lipid profile (10), and if you aren´t exercising, then why are you taking steroids?
To combat the aromatization of testosterone, you can simply take an aromatase inhibitor such as Arimidex. This and other Anti-estrogenic compounds are generally considered a must with testosterone doses over ½ a gram per week (500mgs). Also among side effects (as if acne and going bald aren´t enough) is increased aggression. This is a hotly debated issue in steroid-culture. Generally the consensus is that if you are prone to being a jerk, you´ll be a bigger jerk ...if you aren´t, then your temper will not get much worse (this is supported by research as well Also, high levels of test are generally only associated with aggression and anti-social behavior in males with lower intelligence (1)(2).
Guess what? Dumb people shouldn´t use steroids at all, especially testosterone!
For many, the increased aggression found from increased testosterone levels is often a bonus in the weight room as well as on the playing field. Let´s not get started on its benefits in the bedroom!
Testosterone is also a relatively safe steroid to use, with some studies showing no adverse effects from 20weeks at 600mgs/week! (3)Personally, I have used up to 2 grams per week of various testosterones but now I prefer to keep my dose of it around ½ a gram.
Testosterone is usually attached to an ester (i.e. when you buy testosterone propionate, the subject of this profile, you are buying testosterone with a propionate ester attached). The ester determines how long it takes your body to dispose of the steroid in question, and propionate is the shortest ester available with a testosterone base (of course, testosterone suspension has no ester). There are enzymes, called esterases, in your body which have the function of removing the ester from steroids, and leaving you with just the steroid molecule with the ester cleaved off. Depending on how heavy the ester chain is, that determines how long it takes the esterase to remove it. And that amount of time determines how long the drug stays active in your body. Great, right? Not really...see, the ester takes up "room" in the injection. Check out this chart:
Chemical = Formula = Molecular Weight = Mg of Testosterone
Testosterone (no ester) = C19 H28 O2 = 288.4mg = 100mg
Propionate = C3 H4 O = 56.1mg = 83.72mg
Cypionate = C8 H4 O = 124.2mg = 69.90mg
Here, we´re comparing Testosterone with no ester (suspension) with Test Propionate and Cypionate (basically the longest vs. shortest esters available with testosterone).
So you see, the longer the ester on the testosterone is, the longer the steroid is active in your body, and the less actual test you get. This is because, for every 100mgs of testosterone cypionate you inject, only 69.90mgs of it is actually testosterone, the rest is the cypionate ester, which must be removed. On the other hand, with the propionate ester you´ll get 83.72mgs of Testosterone! The advantage to longer esters is that they need to be injected less frequently (test prop needs to be injected every other day while you can shoot test cyp once a week). The disadvantage to long estered steroids is that they contain less actual steroid. Anecdotally, however, most people from Steroid.com and other discussion boards who have tried differing esters on their various cycles agree: Testosterone Propionate causes the least side effects and the least bloating. For this reason, it´s often the testosterone of choice in cutting cycles. On a personal note, it´s the only form of testosterone I ever use, and it´s the only one most women will use, due to the previously mentioned factors (as well as it´s ability to clear your body quickly upon cessation in the case of side effects). Testosterone levels when you´re using injectable testosterone propionate begin to decline sharply after the second day of use(5). Obviously this is not the drug of choice for those who are squeamish about injections, you´ll be shooting this stuff every other day at least.
Also, as with most steroids, injected testosterone will inhibit your natural test levels and HPTA (Hypothalamic Pituitary Testicular Axis). A mere Hundred mgs of test/week takes about 5-6 weeks to shut the HPTA, and 250-500mgs shuts you down by week 2 (4).
Realistically, every cycle should contain testosterone. Go back and read that sentence again. A beginners´ dose of testosterone (i.e. someone on their first or second cycle of AAS) would be in the 250-500mgs range. Though, realistically, I wouldn´t recommend much less than 400mgs of test per cycle for anybody, beginner or not. And guess what? The more you use the more results you get. And frequently, the more side effects too (3).

Testosterone Propionate Profile

(Testosterone)
4-androstene-3-one, 17beta-ol
Testosterone base + Propionate ester
Molecular Weight (base): 288.429
Molecular Weight (ester): 74.0792
Formula (base): C19 H28 O2
Formula (ester): C3H6O2
Melting Point (base): 155
Melting Point (ester): 21C
Manufacturer: Various
Effective Dose (Men): 350-2000mg+ week.
Effective Dose (Women): 50-100mgs/week
Active life: 2-3 days
Detection Time: 2-3 weeks
Anabolic/Androgenic ratio:100/100.
References:

Pope, H.G, Kouri, E.M., & Hudson, J.I. (2000). Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: A randomized controlled trial. Archives of General Psychiatry, 57, 133-140
Chance, S.E., Brown, R.T., Dabbs, J.M., & Casey, R. (2000). Testosterone, intelligence and behavior disorders among young boys. Personality and Individual Differences, 28, 437-445
Am J Physiol Endocrinol Metab 2003 Jan 7; [epub ahead of print] Related Articles, Links "Development of Models to Predict Anabolic Response to Testosterone Administration in Healthy Young Men."
J Investig Med. 1997 Oct;45(8):441-7
J Clin Endocrinol Metab. 1986 Dec;63(6):1361-4.
J Clin Endocrinol Metab. 1997 Feb;82(2):407-13.
Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7.
Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7.
Curr Pharm Biotechnol. 2004 Oct;5(5):459-70.
Metabolism. 1991 Apr;40(4):368-77.
J Lab Clin Med. 1995 Mar;125(3):326-33.
Zhonghua Nan Ke Xue. 2003;9(4):248-51. Effect of androgen on erythropoientin in patients with hypogonadism] [Article in Chinese]

**Antò** · 27-06-2007, 08:20 AM

Il testosterone fu il primo AAS ad essere sintetizzato, rimane l’unita di paragone di ogni altro AAS.
Il testosterone ha un rapporto anabolico:androgenico di 1:1, ciò significa che ha un potere anabolico pari al suo potere androgenico. Ogni altro AAS verrà paragonato al testosterone per quanto riguarda il suo rapporto anabolico:androgenico. Se uno steroide ha un rapporto di 2:1 vuole dire che la sua capacità anabolica è doppia rispetto al testosterone avendo però un valore pari di androgenicità.

Il testosterone aumenta la massa muscolare grazia alla sua capacità di aumentare la ritenzione di azoto all’interno delle cellule, ciò significa maggiori aminoacidi che vengono captati dal tessuto muscolare. Inoltre aumenta il rilascio da parte del fegato di IGF-1 il quale esplica il compito anabolico del GH sul tessuto magro. L’IGF-1 è inoltre correlato sia all’ipetrofia che all’iperplasia del tessuto muscolare.
Il testosterone possiede anche la capacità di aumentare la presenza di cellule satelliti nel tessuto muscolare, ciò si traduce in una più rapida riparazione delle fibre muscolari danneggiate e quindi in un più rapido recupero. Inoltre, legandosi ai recettori degli androgeni oltre a promuovere la crescita di tessuto muscolare stimola anche la lipolisi.Aumenta l’eritropoiesi (sintesi di globuli rossi) nei reni ed un aumento del conteggio dei globuli rossi migliora la resistenza aumentando l’ossigenazione tissutale. Migliora la contrazione muscolare aumentando il numero di motoneuroni e migliora la trasmissione del segnale neuromuscolare. Tende ad aumentare anche l’attitudine aggressiva e promuove la sintesi di glicogeno migliorando la sensibilità insulinica e quindi il partizionamento calorico a favore del tessuto muscolare.
Sfortunatamente il Testosterone, esogeno compreso, aumenta la produzione di estrogeni grazie alla sua grande affinità con l’enzima aromatase, causa della sua conversione in estrogeni. Ciò comporta:
aumento di acne, ginecomastia (aumento di tessuto mammario), ritenzione di liquidi e quindi aumento della pressione ematica dato dal restringimento dei vasi sanguigni. Inoltre il testosterone interagisce con l’enzima 5-alfa-reduttase che lo converte in DHT, Il Diedro-testosterone ha una maggiore androgenicità rispetto al “padre” ed una maggiore affinità con i recettori situati nello scalpo e nella prostata, ciò comporta aumento della diradazione dei capelli ed ipertrofia prostatica che comporta problemi ad urinare.
Un alto dosaggio di testosterone comporta anche aumento del colesterolo LDL e calo marcato dell’HDL. Probabilmente il testosterone è l’AAS più sicuro in commercio, ma il suo utilizzo non deve essere preso con “leggerezza”

Il testosterone di sintesi normalmente è attaccato ad un estere (come ad esempio il testosterone propionato). L’estere determina il tempo in cui l’organismo disporrà del dato steroide. Il propionate è il testosterone con il più corto estere in commercio (il testosterone in sospensione non ha esteri).
Nel nostro organismo vi sono degli enzimi chiamati “esterase”, questi rimuovono l’estere dallo steroide lasciandolo libero di agire, a seconda della lunghezza della catena esterica avremo un rilascio più lento o rapido dello steroide, difatti la sua lunghezza e correlata al tempo che le esterase impiegano a rompere i legami e liberare lo steroide. Il tempo impiegato determinato quanto lo steroide rimarrà attivo nell’organismo.

Chemical = Formula = Molecular Weight = Mg of Testosterone
Testosterone (no ester) = C19 H28 O2 = 288.4mg = 100mg
Propionate = C3 H4 O = 56.1mg = 83.72mg
Cypionate = C8 H4 O = 124.2mg = 69.90mg

Qui abbiamo il paragone tra il testosterone privo di esteri (in sospensione) con il testo cipionato e propionato (quindi dal più corto al più lungo estere disponibile sul mercato).
Dunque, più lunga è la catena esterica più lunga sarà l’attività dello steroide nell’organismo, ma, come vedete nella tabella, il contenuto di sostanza attiva (il testo in questo caso) è più bassa a seconda della lunghezza dell’estere. Quindi più l’estere attaccato al testo è lungo meno sostanza attiva avremo. L’unico lato positivo di un lungo estere è che la sua assunzione può essere meno frequente. Il lato negativo è che contiene meno testosterone.
Vari feedbacks comunque riportano che il testo propionato causa meno sides e meno ritenzione di liquidi, quindi è molto usato nei cicli di definizione.
Come qualsiasi AAS il testosterone inibisce la produzione endogena di androgeni e la HPTA (Hypothalamic Pituitary Testicular Axis). Bastano soli 100mg di testo a settimana per avere una totale inibizione nel giro di 5 o 6 settimane, se la dose sale a 250/500mg/settimana il totale “shutdown” della HPTA lo avremo in sole 2 settimane.

**Antò** · 10:03 PM

4-androstene-3-one, 17beta-ol
Testosterone base + Propionate ester

Bioattività: 2/3 giorni

Periodo di rilevazione: 3 settimane

Aromatizzazione: Si

Conversione DHT: Si, alta

Acne: Si

Ritenzione di liquidi: Si, alta

Aumento della pressione ematica: Si

Tossicità epatica: Bassa

Inibizione della HPTA: Si, severa

Anabolico/Androgenico: 100/100

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	(#1)
Antò Ruan Messaggi: 1,806 Data registrazione: Mar 2005 Località: catanisi sugnu Età: 42	Testosterone-Propionate - 27-06-2007, 04:17 AM Testosterone-Propionate (testosterone propionate) As we all know, Testosterone was the first steroid to be synthesized. Now, it remains the gold standard of all steroids. First, we´ll discuss Testosterone in general, and in depth, then we´ll examine exactly how (and what) the propionate ester is (together, testosterone propionate is often referred to as just "prop" or "test prop"). Testosterone´s anabolic/androgenic ratio is 1:1 meaning it is exactly as anabolic as it is androgenic. Actually, testosterone is the steroid which all anabolic/androgenic ratio´s are based on. If a steroid is 2:1, then it is, compared with testosterone´s ratio, doubly as anabolic as it is androgenic. Hence, we see from testosterone´s ratio, it is both quite anabolic as well as androgenic. So how exactly does Testosterone build muscle? Well, Testosterone promotes nitrogen retention in the muscle (6), and the more nitrogen the muscles holds the more protein the muscle stores, and the bigger the muscle gets. Testosterone can also increase the levels of another anabolic hormone, IGF-1, in muscle tissue (7). IGF-1 is, alone, highly anabolic and can promote muscle growth. It is responsible for much of the anabolic activity of Growth Hormone (GH). IGF-1 is also one of the few hormones positively correlated with both muscle cell hyperplasia and hyperphasia (this means it both creates more muscle fibers as well as bigger fibers). All of this leads me to speculate that for pure mass, IGF-1, GH, and Testosterone would be a very effective combination. Testosterone also has the amazing ability to increase the activity of satellite cells(8). These cells play a very active role in repairing damaged muscle. Testosterone also binds to the androgen receptor (A.R.) to promote all of the A.R dependant mechanisms for muscle gain and fat loss (9), but clearly, as we´ve seen, this isn´t the only mechanism by which it promotes growth. Testosterone has a profound ability to protect your hard earned muscle from the catabolic (muscle wasting) glucocorticoid hormones (11), and increase red blood cell production (12), and as you may know, a higher RBC count may improve endurance via better oxygenated blood. The former trait increases nitrogen retention and muscle building while the latter can improve recovery from strenuous physical activity, as well as increase endurance and tolerance to strenuous exercise. Testosterone occurs naturally in both the male and female body, as insofar as drug testing for it, typical tests don´t work (i.e. testing for metabolites). Testosterone can be tested for on a testosterone/epitestosterone ratio, a failing result usually being anything over 6 to 1, but there are other more effective tests currently in use as well as being developed by the usual party-poopers in the IOC and FDA. Noteworthy is that if you are using low doses of this drug and stop taking it 36-48 hours before a Test/EpiTest analysis, you can still pass! Testosterone, once in the body, can be converted to both estrogen (via a process known as aromatization) as well as DHT. Estrogen is the main culprit for many side effects such as gyno, water retention, etc...while DHT is often blamed for hair loss and prostate enlargement. Naturally there are ways to combat this, such as using an anti-estrogenic compound along with testosterone, or even an estrogen blocker. DHT can be combated (on the scalp, to prevent hair loss) with compounds such as Ketoconazole shampoo (sold under the trade name Nizoral) as well as Finasteride (sold as Proscar in the 5mg version and as Propecia as 1mg tablets). Interestingly, this shampoo can also be used topically to combat acne on the face (or even the back if you´re really flexible). Both of these methods for preventing hair loss and acne are reasonably effective. However, if you are not prone to hair loss, they may be wholly unnecessary. Male Pattern Baldness (MPB) is carried by the X chromosome, so if your mother´s family boasts men with full heads of hair, then you are probably safe (unless those full heads of hair are all mullets). Naturally, as with most other steroids, your lipid profile is going to suffer a bit while on testosterone as is your blood pressure. This, of course is nothing that can´t be controlled by watching your diet and doing your cardio, at least for the duration of the typical cycle (which for arguments sake, I´ll assume is +/- 12 weeks). Lets be totally honest, here, even a modest amount of exercise will improve your blood pressure and lipid profile (10), and if you aren´t exercising, then why are you taking steroids? To combat the aromatization of testosterone, you can simply take an aromatase inhibitor such as Arimidex. This and other Anti-estrogenic compounds are generally considered a must with testosterone doses over ½ a gram per week (500mgs). Also among side effects (as if acne and going bald aren´t enough) is increased aggression. This is a hotly debated issue in steroid-culture. Generally the consensus is that if you are prone to being a jerk, you´ll be a bigger jerk ...if you aren´t, then your temper will not get much worse (this is supported by research as well Also, high levels of test are generally only associated with aggression and anti-social behavior in males with lower intelligence (1)(2). Guess what? Dumb people shouldn´t use steroids at all, especially testosterone! For many, the increased aggression found from increased testosterone levels is often a bonus in the weight room as well as on the playing field. Let´s not get started on its benefits in the bedroom! Testosterone is also a relatively safe steroid to use, with some studies showing no adverse effects from 20weeks at 600mgs/week! (3)Personally, I have used up to 2 grams per week of various testosterones but now I prefer to keep my dose of it around ½ a gram. Testosterone is usually attached to an ester (i.e. when you buy testosterone propionate, the subject of this profile, you are buying testosterone with a propionate ester attached). The ester determines how long it takes your body to dispose of the steroid in question, and propionate is the shortest ester available with a testosterone base (of course, testosterone suspension has no ester). There are enzymes, called esterases, in your body which have the function of removing the ester from steroids, and leaving you with just the steroid molecule with the ester cleaved off. Depending on how heavy the ester chain is, that determines how long it takes the esterase to remove it. And that amount of time determines how long the drug stays active in your body. Great, right? Not really...see, the ester takes up "room" in the injection. Check out this chart: Chemical = Formula = Molecular Weight = Mg of Testosterone Testosterone (no ester) = C19 H28 O2 = 288.4mg = 100mg Propionate = C3 H4 O = 56.1mg = 83.72mg Cypionate = C8 H4 O = 124.2mg = 69.90mg Here, we´re comparing Testosterone with no ester (suspension) with Test Propionate and Cypionate (basically the longest vs. shortest esters available with testosterone). So you see, the longer the ester on the testosterone is, the longer the steroid is active in your body, and the less actual test you get. This is because, for every 100mgs of testosterone cypionate you inject, only 69.90mgs of it is actually testosterone, the rest is the cypionate ester, which must be removed. On the other hand, with the propionate ester you´ll get 83.72mgs of Testosterone! The advantage to longer esters is that they need to be injected less frequently (test prop needs to be injected every other day while you can shoot test cyp once a week). The disadvantage to long estered steroids is that they contain less actual steroid. Anecdotally, however, most people from Steroid.com and other discussion boards who have tried differing esters on their various cycles agree: Testosterone Propionate causes the least side effects and the least bloating. For this reason, it´s often the testosterone of choice in cutting cycles. On a personal note, it´s the only form of testosterone I ever use, and it´s the only one most women will use, due to the previously mentioned factors (as well as it´s ability to clear your body quickly upon cessation in the case of side effects). Testosterone levels when you´re using injectable testosterone propionate begin to decline sharply after the second day of use(5). Obviously this is not the drug of choice for those who are squeamish about injections, you´ll be shooting this stuff every other day at least. Also, as with most steroids, injected testosterone will inhibit your natural test levels and HPTA (Hypothalamic Pituitary Testicular Axis). A mere Hundred mgs of test/week takes about 5-6 weeks to shut the HPTA, and 250-500mgs shuts you down by week 2 (4). Realistically, every cycle should contain testosterone. Go back and read that sentence again. A beginners´ dose of testosterone (i.e. someone on their first or second cycle of AAS) would be in the 250-500mgs range. Though, realistically, I wouldn´t recommend much less than 400mgs of test per cycle for anybody, beginner or not. And guess what? The more you use the more results you get. And frequently, the more side effects too (3). Testosterone Propionate Profile (Testosterone) 4-androstene-3-one, 17beta-ol Testosterone base + Propionate ester Molecular Weight (base): 288.429 Molecular Weight (ester): 74.0792 Formula (base): C19 H28 O2 Formula (ester): C3H6O2 Melting Point (base): 155 Melting Point (ester): 21C Manufacturer: Various Effective Dose (Men): 350-2000mg+ week. Effective Dose (Women): 50-100mgs/week Active life: 2-3 days Detection Time: 2-3 weeks Anabolic/Androgenic ratio:100/100. References: Pope, H.G, Kouri, E.M., & Hudson, J.I. (2000). Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: A randomized controlled trial. Archives of General Psychiatry, 57, 133-140 Chance, S.E., Brown, R.T., Dabbs, J.M., & Casey, R. (2000). Testosterone, intelligence and behavior disorders among young boys. Personality and Individual Differences, 28, 437-445 Am J Physiol Endocrinol Metab 2003 Jan 7; [epub ahead of print] Related Articles, Links "Development of Models to Predict Anabolic Response to Testosterone Administration in Healthy Young Men." J Investig Med. 1997 Oct;45(8):441-7 J Clin Endocrinol Metab. 1986 Dec;63(6):1361-4. J Clin Endocrinol Metab. 1997 Feb;82(2):407-13. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E601-7. Curr Opin Clin Nutr Metab Care. 2004 May;7(3):271-7. Curr Pharm Biotechnol. 2004 Oct;5(5):459-70. Metabolism. 1991 Apr;40(4):368-77. J Lab Clin Med. 1995 Mar;125(3):326-33. Zhonghua Nan Ke Xue. 2003;9(4):248-51. Effect of androgen on erythropoientin in patients with hypogonadism] [Article in Chinese] Ultima Modifica di Antò : 05-12-2007 09:05 PM.

	(#2)
Antò Ruan Messaggi: 1,806 Data registrazione: Mar 2005 Località: catanisi sugnu Età: 42	27-06-2007, 08:20 AM Il testosterone fu il primo AAS ad essere sintetizzato, rimane l’unita di paragone di ogni altro AAS. Il testosterone ha un rapporto anabolico:androgenico di 1:1, ciò significa che ha un potere anabolico pari al suo potere androgenico. Ogni altro AAS verrà paragonato al testosterone per quanto riguarda il suo rapporto anabolico:androgenico. Se uno steroide ha un rapporto di 2:1 vuole dire che la sua capacità anabolica è doppia rispetto al testosterone avendo però un valore pari di androgenicità. Il testosterone aumenta la massa muscolare grazia alla sua capacità di aumentare la ritenzione di azoto all’interno delle cellule, ciò significa maggiori aminoacidi che vengono captati dal tessuto muscolare. Inoltre aumenta il rilascio da parte del fegato di IGF-1 il quale esplica il compito anabolico del GH sul tessuto magro. L’IGF-1 è inoltre correlato sia all’ipetrofia che all’iperplasia del tessuto muscolare. Il testosterone possiede anche la capacità di aumentare la presenza di cellule satelliti nel tessuto muscolare, ciò si traduce in una più rapida riparazione delle fibre muscolari danneggiate e quindi in un più rapido recupero. Inoltre, legandosi ai recettori degli androgeni oltre a promuovere la crescita di tessuto muscolare stimola anche la lipolisi.Aumenta l’eritropoiesi (sintesi di globuli rossi) nei reni ed un aumento del conteggio dei globuli rossi migliora la resistenza aumentando l’ossigenazione tissutale. Migliora la contrazione muscolare aumentando il numero di motoneuroni e migliora la trasmissione del segnale neuromuscolare. Tende ad aumentare anche l’attitudine aggressiva e promuove la sintesi di glicogeno migliorando la sensibilità insulinica e quindi il partizionamento calorico a favore del tessuto muscolare. Sfortunatamente il Testosterone, esogeno compreso, aumenta la produzione di estrogeni grazie alla sua grande affinità con l’enzima aromatase, causa della sua conversione in estrogeni. Ciò comporta: aumento di acne, ginecomastia (aumento di tessuto mammario), ritenzione di liquidi e quindi aumento della pressione ematica dato dal restringimento dei vasi sanguigni. Inoltre il testosterone interagisce con l’enzima 5-alfa-reduttase che lo converte in DHT, Il Diedro-testosterone ha una maggiore androgenicità rispetto al “padre” ed una maggiore affinità con i recettori situati nello scalpo e nella prostata, ciò comporta aumento della diradazione dei capelli ed ipertrofia prostatica che comporta problemi ad urinare. Un alto dosaggio di testosterone comporta anche aumento del colesterolo LDL e calo marcato dell’HDL. Probabilmente il testosterone è l’AAS più sicuro in commercio, ma il suo utilizzo non deve essere preso con “leggerezza” Il testosterone di sintesi normalmente è attaccato ad un estere (come ad esempio il testosterone propionato). L’estere determina il tempo in cui l’organismo disporrà del dato steroide. Il propionate è il testosterone con il più corto estere in commercio (il testosterone in sospensione non ha esteri). Nel nostro organismo vi sono degli enzimi chiamati “esterase”, questi rimuovono l’estere dallo steroide lasciandolo libero di agire, a seconda della lunghezza della catena esterica avremo un rilascio più lento o rapido dello steroide, difatti la sua lunghezza e correlata al tempo che le esterase impiegano a rompere i legami e liberare lo steroide. Il tempo impiegato determinato quanto lo steroide rimarrà attivo nell’organismo. Chemical = Formula = Molecular Weight = Mg of Testosterone Testosterone (no ester) = C19 H28 O2 = 288.4mg = 100mg Propionate = C3 H4 O = 56.1mg = 83.72mg Cypionate = C8 H4 O = 124.2mg = 69.90mg Qui abbiamo il paragone tra il testosterone privo di esteri (in sospensione) con il testo cipionato e propionato (quindi dal più corto al più lungo estere disponibile sul mercato). Dunque, più lunga è la catena esterica più lunga sarà l’attività dello steroide nell’organismo, ma, come vedete nella tabella, il contenuto di sostanza attiva (il testo in questo caso) è più bassa a seconda della lunghezza dell’estere. Quindi più l’estere attaccato al testo è lungo meno sostanza attiva avremo. L’unico lato positivo di un lungo estere è che la sua assunzione può essere meno frequente. Il lato negativo è che contiene meno testosterone. Vari feedbacks comunque riportano che il testo propionato causa meno sides e meno ritenzione di liquidi, quindi è molto usato nei cicli di definizione. Come qualsiasi AAS il testosterone inibisce la produzione endogena di androgeni e la HPTA (Hypothalamic Pituitary Testicular Axis). Bastano soli 100mg di testo a settimana per avere una totale inibizione nel giro di 5 o 6 settimane, se la dose sale a 250/500mg/settimana il totale “shutdown” della HPTA lo avremo in sole 2 settimane.

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Antò Ruan Messaggi: 1,806 Data registrazione: Mar 2005 Località: catanisi sugnu Età: 42	27-06-2007, 09:33 PM 4-androstene-3-one, 17beta-ol Testosterone base + Propionate ester Bioattività: 2/3 giorni Periodo di rilevazione: 3 settimane Aromatizzazione: Si Conversione DHT: Si, alta Acne: Si Ritenzione di liquidi: Si, alta Aumento della pressione ematica: Si Tossicità epatica: Bassa Inibizione della HPTA: Si, severa Anabolico/Androgenico: 100/100 Ultima Modifica di Antò : 27-06-2007 10:03 PM.